Goldstone Scientific Blog

What's New at Prizmatix for May 2015?

It’s been a while since I have updated the blog and there is plenty to tell you about. Prizmatix now has a convenient new way to shop, in addition to some new and exciting products. Prizmatix products are now available from Amazon.com and the Amazon Business Supply website. We are constantly adding more products. With free two day [...]

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Prizmatix Microscope LEDs, Low Noise and New Low Price

Prizmatix has upgraded their Mic-LED line to a new controller, the BLLC-04, and at the same time lowered their pricing. A complete single wavelength system now costs just $1560. This includes the new BLCC-04 controller, which features advanced low noise driver electronics (<0.03% RMS), and both TTL and analog input for pulsing and intensity control.The [...]

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Med Associates introduces new Optogenetic Fear Conditioning System at SfN 2014 booth #2732

Prizmatix is excited to have their Ultra High Power Optogenetic-LED combined with the popular Med Associates Fear Condition System. This great new combination is available from Med Associates and comes with everything you need from the LED to the fiber implant! As usual, one Prizmatix LED can be used to deliver powerful LED light to two implants for bilateral stimulation, [...]

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Tissue Heating During Optogenetic Experiments Using Laser and LEDs

During a recent LinkedIn conversation regarding light sources for Optogenetics a concern was raised about LEDs causing heating of the tissue. The concern was based on information in a paper “Optogenetics in Neural Systems” published by O Yizhar et al., Neuron, 2011. A careful reading of this paper shows that the concern is relevant only to small LEDs implanted in the tissue, [...]

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Illumination Inside of an Incubator for Optogenetics or Phototoxicity Research

One challenging application we get asked about occasionally is illumination inside of an incubator. These hot, humid and often crowded conditions make it difficult to deliver high intensity light. In one instance, a cardiology researcher using Optogenetics needed intense blue light over an area of microwells to activate channelrhodopsin. There were a number of reasons not to place the Ultra [...]

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​What is Numerical Aperture (NA) and why would a neuroscientist need to know?

Someone once told me that neuroscientists are exceptional. Neuroscientists are not afraid of integrating many areas of knowledge and technology into their research and methods. Well, I can certainly say that neuroscientists have a lot of puzzle pieces to put together to get their research going. And with Optogenetics becoming more widespread I find myself explaining a lot about [...]

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What Is Different About Prizmatix LEDs? – Our Answer to 5 Not-so-Obvious Questions

I recently wrote a blog post called, “Five Not Very Obvious Questions to Ask when Choosing an LED Source for your Fluorescence Microscope.”Well, as I warned – there will be a follow up post with the answers regarding Prizmatix LEDs. 1) How do I choose the LED that will get the most light to the microscope objective?As [...]

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Five Not Very Obvious Questions to Ask when Choosing an LED Source for your Fluorescence Microscope

More and more researchers are considering using an LED source for their fluorescent microscope. There are good reasons to do so, but what are the things you need to be careful about?Some questions such as choosing a spectrum that will be effective are pretty straightforward. But some are not. You might not want to know about [...]

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Three Reason to Consider Replacing Your Mercury or Xenon Lamp with a Prizmatix LED

In the past, research laboratories have relied on mercury or xenon lights as a light source for fluorescence and brightfield microscopy. In recent years however, many researchers have chosen to switch to using LEDs, such as Prizmatix Ultra High Power LEDs instead. Here are three reasons why:1. Prizmatix LEDs are lower cost, more energy-efficient and [...]

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LED Illumination to Eliminate Shutter Vibration Noise

Did you know that using LED illumination can eliminate shutter vibration noise? The following figure was created by a Prizmatix customer to illustrate this advantage:Here is one figure that shows the problem that your LED illuminator solved for us. The figure shows a neuron in a slice filled with a calcium indicator dye. We measure [...]

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